Biliary leak is a troubling complication that arises after a broad range of interventions on the gallbladder, bile ducts, and liver as well as after liver trauma. Fortunately, most biliary leaks are minor. Advances in imaging and minimally invasive interventional techniques have facilitated nonoperative treatment in most cases. The specific clinical scenario dictates diagnosis and treatment of a biliary leak. Prompt diagnosis and treatment lead to optimal clinical outcomes.