TNFa-e microsatellite, HLA-DRB1 and -DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus

Ann N Y Acad Sci. 2006 Oct:1079:300-4. doi: 10.1196/annals.1375.045.

Abstract

TNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1*03 and DQB1*02 allele groups, TNFa1 allele, and the TNFa4-b5-c1-d4-e3 and TNFa10-b5-c1-d4-e3 haplotypes were overrepresented in patients. TNF microsatellite together with HLA polymorphisms is associated with type 1 diabetes in Brazilian patients, corroborating the participation of the MHC genes in disease susceptibility.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles*
  • Brazil / epidemiology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • Gene Frequency
  • HLA Antigens / genetics*
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Haplotypes*
  • Humans
  • Male
  • Microsatellite Repeats*
  • Polymorphism, Genetic
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • HLA Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Tumor Necrosis Factor-alpha