Timing of placental delivery to prevent post-partum haemorrhage: lessons learned from an abandoned randomised clinical trial

Aust N Z J Obstet Gynaecol. 2006 Dec;46(6):549-51. doi: 10.1111/j.1479-828X.2006.00658.x.

Abstract

It has been recognised that, if the length of the third stage of labour exceeds 30 min, then there is an increased risk of a post-partum haemorrhage. Recent information has suggested that 18 min is the optimal time for removal of the undelivered placenta to prevent a post-partum haemorrhage. A randomised trial comparing 20 vs. 30 min was stopped after an interim analysis because only eight of 1607 patients' placentas had not delivered by 20 min. A third stage of labour that exceeded 10 min was observed to be significantly correlated with an increased risk of post-partum haemorrhage.

MeSH terms

  • Adult
  • Delivery, Obstetric / methods*
  • Female
  • Humans
  • Labor Stage, Third*
  • Postpartum Hemorrhage / prevention & control*
  • Pregnancy
  • Randomized Controlled Trials as Topic
  • Time Factors