Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin

Ying-Chieh Tsai; Hui-Chun Hsu; Wen-Chia Yang; Wei-Jern Tsai; Chien-Chih Chen; Takashi Watanabe

doi:10.1016/j.fitote.2006.09.016

Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin

Fitoterapia. 2007 Jan;78(1):7-11. doi: 10.1016/j.fitote.2006.09.016. Epub 2006 Sep 23.

Authors

Ying-Chieh Tsai¹, Hui-Chun Hsu, Wen-Chia Yang, Wei-Jern Tsai, Chien-Chih Chen, Takashi Watanabe

Affiliation

¹ Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan. tsaiyc@ym.edu.tw

PMID: 17107759
DOI: 10.1016/j.fitote.2006.09.016

Abstract

Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography-mass spectrometry (GC-MS). Forty one compounds were identified of which alpha-guaiene (20.62%) and alpha-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P. cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, alpha-bulnesene.

MeSH terms

Animals
Lamiaceae*
Male
Mass Spectrometry
Phytotherapy*
Plant Components, Aerial
Plant Oils / administration & dosage
Plant Oils / chemistry
Plant Oils / pharmacology
Plant Oils / therapeutic use
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / administration & dosage
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology*
Platelet Aggregation Inhibitors / therapeutic use
Rabbits
Sesquiterpenes / administration & dosage
Sesquiterpenes / chemistry
Sesquiterpenes / pharmacology*
Sesquiterpenes / therapeutic use
Sesquiterpenes, Guaiane

Substances

Plant Oils
Platelet Aggregation Inhibitors
Sesquiterpenes
Sesquiterpenes, Guaiane
alpha-bulnesene