Abstract
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Colony Count, Microbial
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Disease Models, Animal
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Exotoxins / genetics
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Exotoxins / physiology*
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Histocytochemistry
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Mice
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Mice, Inbred C57BL
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Pneumonia, Staphylococcal / microbiology*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / pathogenicity*
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Survival Analysis
Substances
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Bacterial Proteins
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Exotoxins
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Membrane Proteins