Feasibility of white-light time-resolved optical mammography

J Biomed Opt. 2006 Sep-Oct;11(5):054035. doi: 10.1117/1.2355663.

Abstract

We demonstrate the feasibility of white-light time-resolved optical mammography. The instrumentation is based on supercontinuum light generated in photonic crystal fiber and 32-channel parallel time-correlated single-photon-counting detection. Total measurement time is of the order of 10 min for typical clinical applications. Preliminary measurements performed on volunteers show the ability of the system to determine tissue constituent concentrations and structure over the entire breast area. Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Neoplasms / diagnosis*
  • Feasibility Studies
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted / instrumentation
  • Image Interpretation, Computer-Assisted / methods*
  • Lasers*
  • Mammography / instrumentation
  • Mammography / methods
  • Middle Aged
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Optical / instrumentation
  • Tomography, Optical / methods*