Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

T S Skinner-Adams; K T Andrews; L Melville; J McCarthy; D L Gardiner

doi:10.1128/AAC.00840-06

Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

Antimicrob Agents Chemother. 2007 Feb;51(2):759-62. doi: 10.1128/AAC.00840-06. Epub 2006 Nov 6.

Authors

T S Skinner-Adams¹, K T Andrews, L Melville, J McCarthy, D L Gardiner

Affiliation

¹ University of Queensland, Department of Medicine, Brisbane, Australia. tinaS@qimr.edu.au

Abstract

The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / pharmacology
Chloroquine / pharmacology*
Drug Synergism
HIV Protease Inhibitors / pharmacology
Humans
Malaria, Falciparum / drug therapy
Mefloquine / pharmacology*
Parasitic Sensitivity Tests
Plasmodium falciparum / drug effects*
Ritonavir / pharmacology*
Saquinavir / pharmacology*

Substances

Antimalarials
HIV Protease Inhibitors
Chloroquine
Saquinavir
Ritonavir
Mefloquine