Abstract
Angiogenesis is fundamental to support the continued synovial proliferation observed in rheumatoid arthritis. We investigated the effects of sulfasalazine and its metabolites on endothelial cell proliferation, a prerequisite to angiogenesis. At concentrations achieved in vivo sulfapyridine inhibited basal and endothelial cell growth factor stimulated endothelial cell proliferation. Sulfasalazine and 5 amino salicylic acid had no effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminosalicylic Acids / pharmacology
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / pathology
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Arthritis, Rheumatoid / physiopathology*
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Cell Division / drug effects
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Humans
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Mesalamine
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Middle Aged
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Monocytes / drug effects
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Neovascularization, Pathologic / pathology
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Sulfasalazine / pharmacology*
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Sulfasalazine / therapeutic use
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Synovial Membrane / blood supply*
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Synovial Membrane / cytology
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Synovial Membrane / drug effects
Substances
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Aminosalicylic Acids
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Sulfasalazine
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Mesalamine