Abstract
The paper analyzes data of an experimental study of the efficacy of antiviral agents (amantadine, remantadine, ozeltamivir, zanamivir, arbidol, ribavirin) in the cultured cells and on a model of murine influenza pneumonia against influenza A viruses subtype H5N1. It also gives data on their use in the treatment of human beings during avian influenza outbreak. The mechanism of action of the agents, pharmacokinetics, adverse reactions, and their potential resistance are considered.
MeSH terms
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Amantadine / therapeutic use
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Animals
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Antiviral Agents / therapeutic use*
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Cell Line
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Disease Models, Animal*
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Humans
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Indoles / therapeutic use
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Influenza A Virus, H5N1 Subtype / drug effects*
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Influenza A Virus, H5N1 Subtype / physiology
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Mice
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Orthomyxoviridae Infections / drug therapy*
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Orthomyxoviridae Infections / virology
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Oseltamivir / therapeutic use
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Ribavirin / therapeutic use
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Rimantadine / therapeutic use
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Virus Replication / drug effects
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Zanamivir / therapeutic use
Substances
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Antiviral Agents
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Indoles
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Rimantadine
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Oseltamivir
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Ribavirin
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umifenovir
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Amantadine
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Zanamivir