Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production

Cell Metab. 2006 Nov;4(5):339-40. doi: 10.1016/j.cmet.2006.10.005.

Abstract

Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.

Publication types

  • Review

MeSH terms

  • DNA-Binding Proteins / physiology*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Glucose / biosynthesis*
  • Humans
  • Liver / metabolism*
  • Nuclear Receptor Subfamily 4, Group A, Member 1
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Receptors, Steroid / physiology*
  • Transcription Factors / physiology*

Substances

  • DNA-Binding Proteins
  • NR4A1 protein, human
  • Nuclear Receptor Subfamily 4, Group A, Member 1
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Transcription Factors
  • Glucose