Abstract
In an initial period (< or =4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / physiology*
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Bacterial Proteins / immunology*
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Caspase 8 / metabolism
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Dendritic Cells / microbiology*
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Dendritic Cells / pathology
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Enzyme Activation / immunology
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Immunoblotting
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Mice
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Signal Transduction / immunology*
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Toll-Like Receptor 4 / metabolism*
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Yersinia Infections / immunology*
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Yersinia enterocolitica / immunology
Substances
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Bacterial Proteins
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Toll-Like Receptor 4
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YopP protein, Yersinia
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Caspase 8