Significant loss of primordial follicles after prolonged gonadotropin stimulation in xenografts of cryopreserved human ovarian tissue in severe combined immunodeficient mice

Theodoros Maltaris; Matthias W Beckmann; Andreas Mueller; Inge Hoffmann; Joachim Kohl; Ralf Dittrich

doi:10.1016/j.fertnstert.2006.05.058

Significant loss of primordial follicles after prolonged gonadotropin stimulation in xenografts of cryopreserved human ovarian tissue in severe combined immunodeficient mice

Fertil Steril. 2007 Jan;87(1):195-7. doi: 10.1016/j.fertnstert.2006.05.058. Epub 2006 Oct 30.

Authors

Theodoros Maltaris¹, Matthias W Beckmann, Andreas Mueller, Inge Hoffmann, Joachim Kohl, Ralf Dittrich

Affiliation

¹ Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen, Germany.

PMID: 17074335
DOI: 10.1016/j.fertnstert.2006.05.058

Abstract

This study evaluated the effect of gonadotropin stimulation on the primordial follicle reserve of cryopreserved human ovarian tissue after transplantation in severe combined immunodeficient mice. We found that prolonged gonadotropin stimulation significantly reduces primordial follicles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cryopreservation / methods*
Female
Gonadotropins / administration & dosage*
Humans
Mice
Mice, SCID
Ovarian Follicle / cytology*
Ovarian Follicle / drug effects*
Ovarian Follicle / transplantation
Ovulation Induction / methods*
Transplantation, Heterologous / methods

Substances

Gonadotropins