CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function

Circ Res. 2006 Oct 27;99(9):911-4. doi: 10.1161/01.RES.0000249616.10603.d6.
No abstract available

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Antigens, CD / metabolism*
  • Antigens, Differentiation, Myelomonocytic / metabolism*
  • Bilirubin / metabolism
  • CD163 Antigen
  • Carbon Monoxide / metabolism
  • Cytoprotection
  • Endocytosis
  • Ferritins / biosynthesis
  • Gene Expression Regulation, Enzymologic
  • Heme / metabolism*
  • Heme Oxygenase-1 / biosynthesis*
  • Heme Oxygenase-1 / genetics
  • Hemoglobins / metabolism*
  • Humans
  • Inflammation Mediators / metabolism
  • Macrophages / enzymology
  • Macrophages / metabolism*
  • Models, Biological
  • Receptors, Cell Surface / metabolism*
  • Transcription, Genetic

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD163 Antigen
  • Hemoglobins
  • Inflammation Mediators
  • Receptors, Cell Surface
  • Heme
  • Carbon Monoxide
  • Ferritins
  • HMOX1 protein, human
  • Heme Oxygenase-1
  • Bilirubin