A new vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with decreased stability of CYP2C9 enzyme

J Thromb Haemost. 2007 Jan;5(1):191-3. doi: 10.1111/j.1538-7836.2006.02261.x. Epub 2006 Oct 12.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Anticoagulants / pharmacokinetics
  • Aryl Hydrocarbon Hydroxylases / genetics
  • Aryl Hydrocarbon Hydroxylases / metabolism*
  • Cytochrome P-450 CYP2C9
  • Drug Resistance / genetics*
  • Enzyme Stability
  • Epistasis, Genetic
  • Female
  • Humans
  • Mixed Function Oxygenases / chemistry
  • Mixed Function Oxygenases / genetics*
  • Molecular Sequence Data
  • Mutation*
  • Protein Conformation
  • Quantitative Trait Loci
  • Vitamin K Epoxide Reductases
  • Warfarin / pharmacokinetics

Substances

  • Anticoagulants
  • Warfarin
  • Mixed Function Oxygenases
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • VKORC1 protein, human
  • Vitamin K Epoxide Reductases