Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments

Rita C Carvalho; Camilla C Patti; André L Takatsu-Coleman; Sonia R Kameda; Claudio F Souza; Lucia Garcez-do-Carmo; Vanessa C Abílio; Roberto Frussa-Filho; Regina H Silva

doi:10.1016/j.brainres.2006.09.008

Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments

Brain Res. 2006 Nov 29;1122(1):179-83. doi: 10.1016/j.brainres.2006.09.008. Epub 2006 Oct 9.

Authors

Rita C Carvalho¹, Camilla C Patti, André L Takatsu-Coleman, Sonia R Kameda, Claudio F Souza, Lucia Garcez-do-Carmo, Vanessa C Abílio, Roberto Frussa-Filho, Regina H Silva

Affiliation

¹ Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil.

PMID: 17030027
DOI: 10.1016/j.brainres.2006.09.008

Abstract

We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic Uptake Inhibitors / pharmacology*
Analysis of Variance
Animals
Avoidance Learning / drug effects*
Discrimination Learning / drug effects*
Disease Models, Animal
Dose-Response Relationship, Drug
Male
Maze Learning / drug effects
Memory Disorders / chemically induced
Memory Disorders / complications*
Mice
Motor Activity / drug effects
Parkinsonian Disorders / chemically induced
Parkinsonian Disorders / complications*
Reserpine / pharmacology*

Substances

Adrenergic Uptake Inhibitors
Reserpine