Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier

J Biomater Sci Polym Ed. 2006;17(8):941-51. doi: 10.1163/156856206777996899.

Abstract

A biodegradable amphiphilic graft polymer was successfully synthesized by grafting hydrophobic poly(1,3-trimethylene carbonate) (PTMC) sequences onto a hydrophilic poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide) (PHEA) backbone. The graft polymer, PHEA-g-PTMC, was synthesized by ring-opening polymerization initiated by the macroinitiator PHEA bearing hydroxyl groups without adding any catalyst. The graft polymer was characterized by Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance spectroscopy, combined size-exclusion chromatography and multiangle laser light scattering analysis. Two drugs with distinct water solubility, prednisone acetate and tegafur, were encapsulated in the PHEA-g-PTMC nanoparticles. The in vitro release of two drugs from PHEA-g-PTMC nanoparticle drug-delivery systems was investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Dioxanes* / chemical synthesis
  • Dioxanes* / chemistry
  • Drug Carriers* / chemical synthesis
  • Drug Carriers* / chemistry
  • Drug Delivery Systems
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Materials Testing
  • Nanostructures
  • Peptides* / chemical synthesis
  • Peptides* / chemistry
  • Polymers* / chemical synthesis
  • Polymers* / chemistry
  • Prednisone / administration & dosage
  • Spectroscopy, Fourier Transform Infrared
  • Surface-Active Agents
  • Tegafur / administration & dosage

Substances

  • Biocompatible Materials
  • Dioxanes
  • Drug Carriers
  • Peptides
  • Polymers
  • Surface-Active Agents
  • alpha,beta-poly((2-hydroxyethyl)-aspartamide)
  • Tegafur
  • polytrimethylene carbonate
  • Prednisone