Abstract
Background:
The somatic type tumors are occasionally found in nonseminomatous germ cell tumors in men. These malignancies are presumed to arise from malignant transformation (MT) of teratoma or by differentiation of totipotential germ cell.
Observation:
A case of MT of germ cell tumor in 17-year-old male into embryonal rhabdomyosarcoma is described. The histopathologic diagnosis was that of embryonal rhabdomyosarcoma in which no germ cell elements were found. The germ cell origin of transformed histology is supported by cytogenetic analysis (isochromosome 12p), and elevated alpha(1)-fetoprotein. Despite intensive therapy the patient died.
Conclusions:
MT of teratoma is rare entity with poor prognosis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Cell Transformation, Neoplastic / genetics*
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Chromosome Aberrations
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Chromosomes, Human, Pair 12 / genetics
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Cytogenetic Analysis
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Fatal Outcome
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Humans
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Immunohistochemistry
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Lung Neoplasms / diagnosis*
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Lung Neoplasms / secondary
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Lymphatic Metastasis
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Male
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Mediastinal Neoplasms / diagnosis*
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Mediastinal Neoplasms / genetics
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Mediastinal Neoplasms / therapy
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Neoplasm, Residual
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Neoplasms, Second Primary / diagnosis*
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Neoplasms, Second Primary / genetics
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Neoplasms, Second Primary / therapy
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Rhabdomyosarcoma, Embryonal / diagnosis*
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Rhabdomyosarcoma, Embryonal / genetics
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Rhabdomyosarcoma, Embryonal / therapy
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Teratoma / diagnosis*
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Teratoma / genetics
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Teratoma / therapy