In this paper, we develop a general framework of a granular representation of ECG signals. The crux of the approach lies in the development and ongoing processing realized in the setting of information granules-fuzzy sets. They serve as basic conceptual and semantically meaningful entities using which we describe signals and build their models (such as various predictive schemes or classifiers). A comprehensive two-phase scheme of the design of the information granules is proposed and described. At the first phase, we discuss the temporal granulation through a series of temporal windows (granular windows) and an aggregation of the values of signal by means of fuzzy sets. To address this issue, offered is a detailed method of building a fuzzy set based on numeric data and a certain optimization criterion that strikes a balance between the highest experimental relevance of the fuzzy set supported by numeric data and its substantial specificity. At the next phase of the granular design, a collection of information granules is further summarized with the use of fuzzy clustering (Fuzzy C-Means). The resulting prototypes (centroids) formed by this grouping process serve as elements of the granular vocabulary. We discuss ways of using these vocabularies in the knowledge-based representation, modeling, and classification of ECG beats.