Lorazepam dose-dependently decreases risk-taking related activation in limbic areas

Psychopharmacology (Berl). 2006 Nov;189(1):105-16. doi: 10.1007/s00213-006-0519-8. Epub 2006 Oct 3.

Abstract

Rationale: Several studies have examined the role of different neurotransmitter systems in modulating risk-taking behavior.

Objective: This investigation was aimed to determine whether the benzodiazepine lorazepam dose-dependently alters risk-taking behavior and underlying neural substrates.

Materials and methods: Fifteen healthy, nonsmoking, individuals (six women, nine men), aged 18-39 years (mean 27.6 +/- 1.4 years) with 12-18 years of education (mean 15.6 +/- 0.3 years) underwent functional magnetic resonance imaging while performing a risk-taking decision-making task.

Results: Our results show that lorazepam did not affect risky behavior at 0.25 and 1 mg, but dose-dependently attenuated activation in (a) the amygdala and medial prefrontal cortex during the response selection phase, and in (b) the bilateral insular cortex and amygdala during the outcome (i.e., rewarded or punished) phase. Furthermore, a lorazepam-induced increase in insular cortex activation was associated with less risky responses.

Conclusions: Taken together, our findings support the idea that GABAergic modulation in limbic and paralimbic structures is important during both the response selection and outcome phase of risk-taking decision-making.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Amygdala / drug effects
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology*
  • Brain Mapping
  • Decision Making / drug effects*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • GABA Agonists / administration & dosage
  • GABA Agonists / pharmacology*
  • Humans
  • Limbic System / drug effects*
  • Lorazepam / administration & dosage
  • Lorazepam / pharmacology*
  • Magnetic Resonance Imaging
  • Male
  • Prefrontal Cortex / drug effects
  • Punishment
  • Reference Values
  • Reward
  • Risk-Taking*

Substances

  • Anti-Anxiety Agents
  • GABA Agonists
  • Lorazepam