Abstract
Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Antigens, Differentiation, T-Lymphocyte
-
B-Lymphocytes / immunology*
-
CD40 Ligand
-
Cell Communication / immunology
-
Female
-
Humans
-
Immunologic Memory / immunology
-
Inducible T-Cell Co-Stimulator Protein
-
Interleukin-10 / metabolism*
-
Interleukin-4 / metabolism*
-
Lymphocyte Subsets / immunology
-
Male
-
Receptors, Antigen, T-Cell, gamma-delta / analysis*
-
Receptors, CXCR5
-
Receptors, Chemokine / analysis*
-
T-Lymphocytes / chemistry
-
T-Lymphocytes / immunology*
-
T-Lymphocytes / metabolism
Substances
-
Antigens, Differentiation, T-Lymphocyte
-
CXCR5 protein, human
-
ICOS protein, human
-
Inducible T-Cell Co-Stimulator Protein
-
Receptors, Antigen, T-Cell, gamma-delta
-
Receptors, CXCR5
-
Receptors, Chemokine
-
Interleukin-10
-
CD40 Ligand
-
Interleukin-4