Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans

J C Bowman; G K Abruzzo; A M Flattery; C J Gill; E J Hickey; M J Hsu; J Nielsen Kahn; P A Liberator; A S Misura; B A Pelak; T C Wang; C M Douglas

doi:10.1128/AAC.00485-06

Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans

Antimicrob Agents Chemother. 2006 Dec;50(12):4202-5. doi: 10.1128/AAC.00485-06. Epub 2006 Oct 2.

Authors

J C Bowman¹, G K Abruzzo, A M Flattery, C J Gill, E J Hickey, M J Hsu, J Nielsen Kahn, P A Liberator, A S Misura, B A Pelak, T C Wang, C M Douglas

Affiliation

¹ Department of Infectious Disease Research, Merck Research Laboratories, RY80Y-260, P.O. Box 2000, Rahway, NJ 07065-0900, USA. joel_bowman@merck.com

Abstract

The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

Publication types

Comparative Study

MeSH terms

Animals
Antifungal Agents / therapeutic use*
Aspergillus / drug effects*
Aspergillus flavus / drug effects*
Aspergillus nidulans / drug effects*
Caspofungin
Disease Models, Animal
Dose-Response Relationship, Drug
Echinocandins
Female
Lipopeptides
Mice
Mice, Inbred DBA
Microbial Sensitivity Tests
Peptides, Cyclic / therapeutic use*
Survival Analysis
Time Factors
Treatment Outcome

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides, Cyclic
Caspofungin