Abstract
Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase-1 in the lung tissue and that administration of antioxidant N-acetyl-l-cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase-3 lung immunohistochemistry, and against emphysema.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acetylcysteine / pharmacology*
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Acetylcysteine / therapeutic use
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Animals
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Apoptosis / drug effects*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Emphysema / chemically induced
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Emphysema / metabolism
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Emphysema / prevention & control*
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Heme Oxygenase-1 / metabolism*
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Hypertrophy, Right Ventricular / prevention & control
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Indoles / pharmacology
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Lung / cytology
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Lung / metabolism*
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Male
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Oxidative Stress
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Pyrroles / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors*
Substances
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Indoles
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Pyrroles
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Semaxinib
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Heme Oxygenase-1
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Receptors, Vascular Endothelial Growth Factor
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Acetylcysteine