Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon

Wassim Y Almawi; Saria F Wakim-Ghorayeb; Mona R Arekat; Pierre Najm; Sose H Keleshian; Nasreen Al-Sayed; Bruno Blanchon; Hanady R Samaha; Noha Irani-Hakime

doi:10.1128/CVI.00206-06

Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon

Clin Vaccine Immunol. 2006 Nov;13(11):1296-8. doi: 10.1128/CVI.00206-06. Epub 2006 Sep 20.

Authors

Wassim Y Almawi¹, Saria F Wakim-Ghorayeb, Mona R Arekat, Pierre Najm, Sose H Keleshian, Nasreen Al-Sayed, Bruno Blanchon, Hanady R Samaha, Noha Irani-Hakime

Affiliation

¹ Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. wyalmawi@yahoo.co.uk

Abstract

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

Publication types

Comparative Study

MeSH terms

Alleles
Bahrain
Diabetes Mellitus, Type 2 / genetics*
Diabetes Mellitus, Type 2 / immunology
Female
Genetic Predisposition to Disease*
HLA-DQ Antigens / genetics*
HLA-DQ beta-Chains
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Haplotypes*
Humans
Lebanon
Male
Middle Aged

Substances

HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB1*11:01:01 antigen