Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization

Org Lett. 2006 Sep 28;8(20):4469-71. doi: 10.1021/ol061615p.

Abstract

We report a method for the synthesis of chiral pyrrolidines using tin-lithium exchange and cyclization reactions. The precursors are formed readily from simple starting materials and undergo tin-lithium exchange by treatment with n-butyllithium. Subsequent intramolecular carbolithiation is stereoselective to give highly enantiomerically enriched pyrrolidines in excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Lithium / chemistry*
  • Magnetic Resonance Spectroscopy
  • Pyrrolidines / chemical synthesis*
  • Stereoisomerism
  • Tin / chemistry*

Substances

  • Pyrrolidines
  • Tin
  • Lithium