Cotranslocational degradation: utilitarianism in the ER stress response

Mol Cell. 2006 Sep 15;23(6):773-5. doi: 10.1016/j.molcel.2006.08.024.

Abstract

Recently, a new layer of the unfolded protein response was discovered that supports the cotranslocational degradation of nascent chains stalled in endoplasmic reticulum translocons (Oyadomari et al., 2006).

Publication types

  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Membrane Proteins / metabolism
  • Mice
  • Models, Biological*
  • Protein Biosynthesis / physiology*
  • Protein Folding
  • Proteins / metabolism*
  • Signal Transduction

Substances

  • Membrane Proteins
  • Proteins