The modulatory effects of phorbol esters on histamine release from mast cells induced by a polyethylenimine and a polyallylamine

Gen Pharmacol. 1990;21(4):535-9. doi: 10.1016/0306-3623(90)90710-4.

Abstract

1. Histamine release from rat peritoneal mast cells induced by polyethylenimine (mol. wt = 600) was inhibited by phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), but not by 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD). 2. Histamine release induced by polyallylamine (mol. wt = 10,000) was enhanced by PMA and PDBu, but not by 4 alpha-PDD. 3. K-252a reduced the inhibitory effect of PMA on histamine release induced by polyethylenimine and its enhancing effect on histamine release by polyallylamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Histamine Release / drug effects*
  • In Vitro Techniques
  • Male
  • Mast Cells / drug effects
  • Mast Cells / enzymology
  • Mast Cells / metabolism*
  • Molecular Weight
  • Phorbol 12,13-Dibutyrate / pharmacology
  • Phorbol Esters / pharmacology*
  • Polyamines / pharmacology*
  • Polyethyleneimine / pharmacology*
  • Polyethylenes / pharmacology*
  • Protein Kinase C / metabolism
  • Rats
  • Rats, Inbred Strains
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Phorbol Esters
  • Polyamines
  • Polyethylenes
  • phorbol-12,13-didecanoate
  • polyallylamine
  • Phorbol 12,13-Dibutyrate
  • Polyethyleneimine
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate