Clinical studies with ropinirole in Parkinson's disease and RLS

J Neurol. 2006 Aug:253 Suppl 4:IV16-21. doi: 10.1007/s00415-006-4004-4.

Abstract

Ropinirole is a modern dopamine agonist with a half-life of medium extent that is highly selective for D(2)-receptors. Ropinirole is an indole derivative and thus does not belong to the group of ergoline dopamine receptor agonists. Its effect has been proved in a number of controlled studies in both monotherapy and combination treatments of Parkinson's disease. We can meanwhile refer to the long-term data of studies that have been run for more than 10 years. The substance has also been approved for the management of restless legs syndrome. A long-acting formula of the substance will be available soon.

MeSH terms

  • Antiparkinson Agents / therapeutic use*
  • Dopamine Agonists / therapeutic use
  • Humans
  • Indoles / therapeutic use*
  • Parkinson Disease / drug therapy*
  • Randomized Controlled Trials as Topic
  • Restless Legs Syndrome / drug therapy*

Substances

  • Antiparkinson Agents
  • Dopamine Agonists
  • Indoles
  • ropinirole