Abstract
The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associated event, occurred at a site located within the beta/A4 region. This suggests that an intact amyloidogenic beta/A4 fragment is not generated during normal APP catabolism. Therefore, an early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact beta/A4.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Alzheimer Disease / metabolism*
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Amyloid / genetics
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Amyloid / metabolism*
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Animals
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Cell Membrane
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Cells, Cultured
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Cloning, Molecular
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DNA, Recombinant
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Glycosylation
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Half-Life
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Humans
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Immunoblotting
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Molecular Weight
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Plasmids
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Protein Precursors / genetics
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Protein Precursors / metabolism*
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Protein Processing, Post-Translational*
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Recombinant Fusion Proteins / metabolism
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Substance P / genetics
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Transfection
Substances
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Amyloid
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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DNA, Recombinant
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Protein Precursors
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Recombinant Fusion Proteins
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Substance P