Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies

Hong Kong Med J. 2006 Aug;12(4):319-21.

Abstract

A middle-aged man presented with bone pain at multiple sites due to tumour-induced osteomalacia. The underlying occult phosphaturic mesenchymal tumour was identified by octreotide scan 5 years after presentation and confirmed by computed tomography. Tumour resection resulted in normalisation of blood chemistry and bone densitometry. Clinico-radiologico-pathological correlation and ultrastructural studies of the tumour threw light on the pathogenesis and pathophysiology of this rare disease.

Publication types

  • Case Reports

MeSH terms

  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / genetics
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Connective and Soft Tissue / complications
  • Neoplasms, Connective and Soft Tissue / diagnostic imaging
  • Neoplasms, Connective and Soft Tissue / pathology*
  • Neoplasms, Connective and Soft Tissue / ultrastructure
  • Osteomalacia / etiology*
  • Phosphates / urine*
  • Radiography

Substances

  • Phosphates
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23