Histaminergic neurons receive substance P-ergic inputs in the posterior hypothalamus of the rat

R Tamiya; M Hanada; N Narita; S Inagaki; M Tohyama; H Takagi

doi:10.1007/BF00608234

Histaminergic neurons receive substance P-ergic inputs in the posterior hypothalamus of the rat

Exp Brain Res. 1990;79(2):261-5. doi: 10.1007/BF00608234.

Authors

R Tamiya¹, M Hanada, N Narita, S Inagaki, M Tohyama, H Takagi

Affiliation

¹ First Department of Anatomy, Osaka City University Medical School, Japan.

PMID: 1691105
DOI: 10.1007/BF00608234

Abstract

The synaptic connections between histaminergic neurons and substance P (SP) afferents in the caudal magnocellular nucleus (CM) of the hypothalamus were examined using an immunoelectron microscopic mirror method. SP-immunoreactive (SP-IR) terminals made synaptic contacts with the somata, somatic spines and dendrites of histidine decarboxylase immunoreactive (HDC-IR) neurons. This suggests that SP afferents exert monosynaptic influence on the central histaminergic neuronal system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Histamine / metabolism*
Hypothalamus / metabolism*
Hypothalamus, Posterior / cytology
Hypothalamus, Posterior / metabolism*
Immunohistochemistry
Male
Rats
Rats, Inbred Strains
Substance P / metabolism*

Substances

Substance P
Histamine