Phenethyl alcohol disorders phospholipid acyl chains and promotes translocation of the mitochondrial precursor protein apocytochrome c across a lipid bilayer

FEBS Lett. 1990 Feb 12;261(1):55-8. doi: 10.1016/0014-5793(90)80635-v.

Abstract

The interaction of phenethyl alcohol with model membranes and its effect on translocation of the chemically prepared mitochondrial precursor protein apocytochrome c across a lipid bilayer was studied. Phenethyl alcohol efficiently penetrates into monolayers and causes acyl chain disordering judged from deuterium nuclear magnetic resonance measurements with specific acyl chain-deuterated phospholipids. Translocation of apocytochrome c across a phospholipid bilayer was stimulated on addition of phenethyl alcohol indicating that the efficiency of translocation of this precursor protein is enhanced due to a disorder of the acyl chain region of the bilayer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoproteins / metabolism*
  • Biological Transport / drug effects
  • Cytochrome c Group / metabolism*
  • Cytochromes c
  • Ethanol / analogs & derivatives*
  • Lipid Bilayers / metabolism*
  • Magnetic Resonance Spectroscopy
  • Membrane Lipids / metabolism*
  • Mitochondria / metabolism
  • Phenylethyl Alcohol / pharmacology*
  • Phosphatidylcholines / metabolism
  • Phosphatidylethanolamines / metabolism
  • Phosphatidylserines / metabolism
  • Phospholipids / metabolism*
  • Protein Precursors / metabolism
  • Trypsin / metabolism

Substances

  • Apoproteins
  • Cytochrome c Group
  • Lipid Bilayers
  • Membrane Lipids
  • Phosphatidylcholines
  • Phosphatidylethanolamines
  • Phosphatidylserines
  • Phospholipids
  • Protein Precursors
  • Ethanol
  • 1,2-dioleoylphosphatidylserine
  • 1,2-dielaidoylphosphatidylethanolamine
  • Cytochromes c
  • Trypsin
  • 1,2-oleoylphosphatidylcholine
  • Phenylethyl Alcohol