Vaccine clinical trials--a statistical primer

J Biopharm Stat. 2006;16(4):403-14. doi: 10.1080/10543400600719194.

Abstract

We discuss some of the key statistical issues that arise in all stages of vaccine development and, where necessary, contrast drug and vaccine clinical trials.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Design
  • Drug Evaluation, Preclinical / methods
  • Drug Evaluation, Preclinical / statistics & numerical data
  • Humans
  • Models, Statistical*
  • Randomized Controlled Trials as Topic / methods
  • Randomized Controlled Trials as Topic / statistics & numerical data*
  • Vaccines / adverse effects
  • Vaccines / chemical synthesis
  • Vaccines / immunology
  • Vaccines / therapeutic use*

Substances

  • Vaccines