Cortical correlates of TMS-induced phantom hand movements revealed with concurrent TMS-fMRI

Neuropsychologia. 2006;44(14):2959-71. doi: 10.1016/j.neuropsychologia.2006.06.023. Epub 2006 Aug 4.

Abstract

We studied an amputee patient who experiences a conscious sense of movement (SoM) in her phantom hand, without significant activity in remaining muscles, when transcranial magnetic stimulation (TMS) is applied at appropriate intensity over the corresponding sector of contralateral motor cortex. We used the novel methodological combination of TMS during fMRI to reveal the neural correlates of her phantom SoM. A critical contrast concerned trials at intermediate TMS intensities: low enough not to produce overt activity in remaining muscles; but high enough to produce a phantom SoM on approximately half such trials. Comparing trials with versus without a phantom SoM reported phenomenally, for the same intermediate TMS intensities, factored out any non-specific TMS effects on brain activity to reveal neural correlates of the phantom SoM itself. Areas activated included primary motor cortex, dorsal premotor cortex, anterior intraparietal sulcus, and caudal supplementary motor area, regions that are also involved in some hand movement illusions and motor imagery in normals. This adds support to proposals that a conscious sense of movement for the hand can be conveyed by activity within corresponding motor-related cortical structures.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amputees
  • Brain Mapping
  • Cerebral Cortex* / blood supply
  • Cerebral Cortex* / physiopathology
  • Electromyography / methods
  • Evoked Potentials / physiology
  • Female
  • Functional Laterality
  • Hand / innervation
  • Hand / physiopathology*
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging*
  • Movement*
  • Muscle, Skeletal / physiopathology
  • Oxygen / blood
  • Phantom Limb / physiopathology*
  • Transcranial Magnetic Stimulation*

Substances

  • Oxygen