Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

Jenny K Ekegren; Johan Gising; Hans Wallberg; Mats Larhed; Bertil Samuelsson; Anders Hallberg

doi:10.1039/b606859f

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

Org Biomol Chem. 2006 Aug 21;4(16):3040-3. doi: 10.1039/b606859f. Epub 2006 Jul 6.

Authors

Jenny K Ekegren¹, Johan Gising, Hans Wallberg, Mats Larhed, Bertil Samuelsson, Anders Hallberg

Affiliation

¹ Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.

PMID: 16886068
DOI: 10.1039/b606859f

Abstract

A short synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains has been developed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry*
Crystallography, X-Ray
HIV Protease Inhibitors / chemistry*
HIV-1 / enzymology*

Substances

Alcohols
HIV Protease Inhibitors