The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22

Genomics. 1991 Oct;11(2):374-8. doi: 10.1016/0888-7543(91)90145-5.

Abstract

TFE3, a member of the helix-loop-helix family of transcription factors, binds to the microE3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types. We have localized human TFE3 to the proximal short arm of the X chromosome using a somatic cell hybrid panel. A frequent RsaI RFLP detected by the TFE3 cDNA was found and used to confirm this location by linkage analysis in 20 pedigrees. Two-point and multipoint lod scores place TFE3 near markers in Xp11.22 with the most likely order DXS7-DXS255-TFE3-DXS146-DXS14.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cell Line
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human
  • Cricetinae
  • Crossing Over, Genetic
  • DNA Probes
  • DNA-Binding Proteins / genetics*
  • Enhancer Elements, Genetic / genetics
  • Humans
  • Immunoglobulin Heavy Chains / genetics*
  • Lod Score
  • Polymorphism, Restriction Fragment Length
  • Transcription Factors / genetics*
  • X Chromosome*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • DNA Probes
  • DNA-Binding Proteins
  • Immunoglobulin Heavy Chains
  • TFE3 protein, human
  • Transcription Factors