Our study revealed morphological changes in the two organs of Guinea pig kidney and suprarenal gland exposed to hyperbaric-hyperoxic environment. Proceeding from these data and knowing that in hyperbaric-hyperoxic environment the production of free oxygen radicals is increased, while the afferent arterioles undergo vasoconstriction, with direct implications on the cellular metabolism, our study puts forth the survey of the influence of hyperoxic environment on kidneys and adrenal gland - complex organs which are exposed to stress.