Total synthesis of the marine natural product (-)-clavosolide A

Conor S Barry; Jon D Elsworth; Peter T Seden; Nick Bushby; John R Harding; Roger W Alder; Christine L Willis

doi:10.1021/ol0611705

Total synthesis of the marine natural product (-)-clavosolide A

Org Lett. 2006 Jul 20;8(15):3319-22. doi: 10.1021/ol0611705.

Authors

Conor S Barry¹, Jon D Elsworth, Peter T Seden, Nick Bushby, John R Harding, Roger W Alder, Christine L Willis

Affiliation

¹ School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.

PMID: 16836395
DOI: 10.1021/ol0611705

Abstract

[Structure: see text] The total synthesis of the marine metabolite clavosolide A is reported which confirms the structure and absolute configuration of the natural product as the symmetrical diolide glycosylated by permethylated D-xylose moieties, 2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemical synthesis*
Biological Products / chemistry
Catalysis
Macrolides / chemical synthesis*
Macrolides / chemistry
Marine Biology
Molecular Structure
Stereoisomerism

Substances

Biological Products
Macrolides
clavosolide A