A magnetic biomimetic nanocatalyst for cleaving phosphoester and carboxylic ester bonds under mild conditions

Org Lett. 2006 Jul 20;8(15):3215-7. doi: 10.1021/ol061098a.

Abstract

[Structure: see text] As a result of the unique surface structure of nanospheres, Asp and His residues supported on a 12 nm maghemite nanoparticle worked collaboratively as a biomimetic nanocatalyst for hydrolyzing paraoxon (phosphoester) and 4-nitrophenyl acetate (carboxylic ester) in Milli-Q water (pH 7.0) at 37 degrees C, without employing extremes of pH or heavy metals. Our nanocatalyst could be facilely recovered via magnetic concentration. The isolated catalyst exhibited long-term stability, showing no significant loss of its catalytic activity for repeated uses after 3 months.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry
  • Aspartic Acid / chemistry
  • Catalysis
  • Esters
  • Histidine / chemistry
  • Hydrogen-Ion Concentration
  • Indicators and Reagents
  • Molecular Mimicry
  • Molecular Structure
  • Nanotubes / chemistry*
  • Organophosphorus Compounds / chemistry*

Substances

  • Amino Acids
  • Esters
  • Indicators and Reagents
  • Organophosphorus Compounds
  • Aspartic Acid
  • Histidine