A brief history of RNAi: the silence of the genes

FASEB J. 2006 Jul;20(9):1293-9. doi: 10.1096/fj.06-6014rev.

Abstract

The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Argonaute Proteins
  • Eukaryotic Initiation Factor-2
  • Gene Silencing
  • Humans
  • Peptide Initiation Factors / genetics
  • RNA Interference*
  • RNA, Double-Stranded / genetics
  • RNA, Messenger / genetics
  • Ribonuclease III / genetics

Substances

  • AGO2 protein, human
  • Argonaute Proteins
  • Eukaryotic Initiation Factor-2
  • Peptide Initiation Factors
  • RNA, Double-Stranded
  • RNA, Messenger
  • Ribonuclease III