APPLied mechanics: uncovering how adiponectin modulates insulin action

Sarah E Hosch; Jerrold M Olefsky; Jane J Kim

doi:10.1016/j.cmet.2006.06.003

APPLied mechanics: uncovering how adiponectin modulates insulin action

Cell Metab. 2006 Jul;4(1):5-6. doi: 10.1016/j.cmet.2006.06.003.

Authors

Sarah E Hosch¹, Jerrold M Olefsky, Jane J Kim

Affiliation

¹ Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

PMID: 16814726
DOI: 10.1016/j.cmet.2006.06.003

Abstract

Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing / physiology*
Adiponectin / metabolism*
Animals
Carrier Proteins / physiology*
Humans
Insulin / metabolism*
Models, Biological
Receptors, Cell Surface / metabolism
Signal Transduction / physiology

Substances

APPL1 protein, human
Adaptor Proteins, Signal Transducing
Adiponectin
Appl1 protein, mouse
Carrier Proteins
Insulin
Receptors, Cell Surface