Abstract
The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.
MeSH terms
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Factor VIIa / antagonists & inhibitors*
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Factor VIIa / metabolism
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology*
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Molecular Structure
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Structure-Activity Relationship
Substances
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Indoles
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Pyridines
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Factor VIIa