There is little information on patients 50 years or older with HIV infection since the start of the HAART era. We performed a descriptive cross-sectional study during 2004 including 28 patients aged 52 to 87 years. Eighteen patients were men (64%) and sexual transmission was the risk factor in 23 (81%). Four patients (14%) fulfilled slow progression criteria and 13 (46%) belonged to the C3 category. Twenty-four patients were on HAART, with optimal adherence. All the patients were receiving HIV-unrelated medications to treat comorbid conditions. Hence, the profile of these patients is as follows: mainly male with sexually transmitted infection, severe immunodeficiency at the diagnosis, and frequent comorbid processes.