Abstract
1. After drug discontinuation and 1 week placebo washout, 12 patients with panic disorders received, for 6 weeks, either placebo or sodium divalproex. During 6 consecutive weeks, alternate medication was given. 2. Severity of panic and anxiety attacks was improved only in patients receiving sodium divalproex as a first medication. 3. Protracted benzodiazepine effects may occur in the dichotomous antipanic activity of sodium divalproex.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Anxiety Agents / adverse effects
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Anti-Anxiety Agents / therapeutic use*
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Anxiety Disorders / drug therapy*
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Anxiety Disorders / psychology
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Benzodiazepines
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Double-Blind Method
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Drug Interactions
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Female
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Humans
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Male
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Mental Disorders / drug therapy*
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Mental Disorders / psychology
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Panic / drug effects*
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Psychiatric Status Rating Scales
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Recurrence
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Valproic Acid / therapeutic use*
Substances
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Anti-Anxiety Agents
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Benzodiazepines
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Valproic Acid