The nephrotoxicity of 2,5-dichloro-3-(glutathion-S-yl)-1,4-benzoquinone, and 2,5,6-trichloro-3-(glutathion-S-yl)-1,4-benzoquinone is potentiated by ascorbic acid and AT-125

Adv Exp Med Biol. 1991:283:767-9. doi: 10.1007/978-1-4684-5877-0_103.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Ascorbic Acid / toxicity
  • Blood Urea Nitrogen
  • Chloranil / analogs & derivatives*
  • Chloranil / toxicity
  • Drug Synergism
  • Glutathione / analogs & derivatives*
  • Glutathione / metabolism
  • Glutathione / toxicity
  • Isoxazoles / toxicity
  • Kidney / drug effects*
  • Kidney / metabolism
  • Rats
  • gamma-Glutamyltransferase / metabolism

Substances

  • Isoxazoles
  • Chloranil
  • 2-gluthionyl-3,5,6-trichloro-1,4-benzoquinone
  • 2,5-dichloro-3-(glutathionyl-S-yl)-1,4-benzoquinone
  • gamma-Glutamyltransferase
  • Glutathione
  • acivicin
  • Ascorbic Acid