Dual role of the adaptor protein SLP-65: organizer of signal transduction and tumor suppressor of pre-B cell leukemia

Immunol Res. 2006;34(2):143-55. doi: 10.1385/IR:34:2:143.

Abstract

B cell development is characterized by a coordinated progression through defined stages that are controlled at several checkpoints. Signals from the pre-B cell receptor (pre-BCR) are essential for regulated transition from the pre-B cell stage. The adaptor protein SLP-65 plays a key role in this signaling pathway. Recent findings indicate an additional function of SLP-65 as a tumor suppressor that regulates pre-B cell proliferation. We will discuss here the potential mechanisms by which SLP-65 controls the pre-B cell checkpoint.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Agammaglobulinaemia Tyrosine Kinase
  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / physiology
  • Carrier Proteins / physiology*
  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Membrane Glycoproteins / metabolism
  • Phosphoproteins / physiology*
  • Pre-B Cell Receptors
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / physiopathology*
  • Protein-Tyrosine Kinases
  • Receptors, Antigen, B-Cell
  • Signal Transduction*
  • Tumor Suppressor Proteins / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • B cell linker protein
  • Carrier Proteins
  • Membrane Glycoproteins
  • Phosphoproteins
  • Pre-B Cell Receptors
  • Receptors, Antigen, B-Cell
  • Tumor Suppressor Proteins
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase