Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function

Steven J Clapcote; John C Roder

doi:10.1534/genetics.106.060749

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function

Genetics. 2006 Aug;173(4):2407-10. doi: 10.1534/genetics.106.060749. Epub 2006 Jun 4.

Authors

Steven J Clapcote¹, John C Roder

Affiliation

¹ Mount Sinai Hospital Research Institute, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. clapcote@mshri.on.ca

Abstract

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Base Sequence*
Brain / physiology*
Embryo, Mammalian / cytology
Embryo, Mammalian / physiology
Gene Targeting* / methods
Humans
Mice
Mice, Inbred Strains
Mice, Knockout
Nerve Tissue Proteins / genetics*
Polymorphism, Genetic*
Sequence Deletion*
Species Specificity
Stem Cells / cytology
Stem Cells / physiology

Substances

Disc1 protein, mouse
Nerve Tissue Proteins