A phosphatase controls the fate of receptor-regulated Smads

Cell. 2006 Jun 2;125(5):838-40. doi: 10.1016/j.cell.2006.05.015.

Abstract

In this issue of Cell, Lin et al. (2006) answer one of the long-standing questions in the TGFbeta field by identifying a phosphatase, PPM1A, that directly dephosphorylates Smad2 and Smad3 to limit their activation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Humans
  • Phosphoprotein Phosphatases / genetics
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Receptors, Transforming Growth Factor beta / metabolism
  • Signal Transduction / physiology
  • Smad2 Protein / metabolism*
  • Smad3 Protein / metabolism*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Receptors, Transforming Growth Factor beta
  • Smad2 Protein
  • Smad3 Protein
  • Transforming Growth Factor beta
  • Phosphoprotein Phosphatases