Abstract
The total synthesis of paeonilide, a natural anti-PAF (platelet-activating factor) new skeleton monoterpenoid with an IC(50) value of 8 microg/mL, was achieved in 16 steps with 15% overall yield from commercially available 2-hydroxy-4-methylacetophenone. [reaction: see text]
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Paeonia / chemistry
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Plant Roots / chemistry
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Plants, Medicinal / chemistry
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Platelet Activating Factor / antagonists & inhibitors
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Platelet Activating Factor / chemical synthesis*
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Platelet Activating Factor / chemistry
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Stereoisomerism
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Terpenes / chemical synthesis*
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Terpenes / chemistry
Substances
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2-hydroxy-4-methylacetophenone
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Acetophenones
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Platelet Activating Factor
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Terpenes
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paeonilide