HIF-1 and tumour radiosensitivity

Br J Cancer. 2006 Jul 3;95(1):1-5. doi: 10.1038/sj.bjc.6603201. Epub 2006 May 30.

Abstract

Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Hypoxia / radiation effects*
  • Gene Expression Regulation, Neoplastic / radiation effects
  • Humans
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / physiology*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Radiation Tolerance*

Substances

  • Hypoxia-Inducible Factor 1