Recombinant expression of Toluene o-Xylene Monooxygenase (ToMO) from Pseudomonas stutzeri OX1 in the marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

J Biotechnol. 2006 Nov 10;126(3):334-41. doi: 10.1016/j.jbiotec.2006.04.027. Epub 2006 May 30.

Abstract

The psychrophilic bacterium Pseudoalteromonas haloplanktis TAC125, isolated from Antarctic seawater, was used as recipient for a biodegradative gene of the mesophilic Pseudomonas stutzeri OX1. tou cluster, coding for Toluene o-Xylene Monooxygenase (ToMO), was successfully cloned and expressed into a "cold expression" vector. Apparent catalytic parameters of the recombinant microorganisms on three different substrates were determined and compared with those exhibited by Escherichia coli recombinant cells expressing ToMO. Production of a catalytically efficient TAC/tou microorganism supports the possibility of developing specific degradative capabilities for the bioremediation of chemically contaminated marine environments and of industrial effluents characterised by low temperatures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antarctic Regions
  • Gene Expression / physiology
  • Marine Biology
  • Oxygenases / chemistry*
  • Oxygenases / genetics
  • Oxygenases / metabolism*
  • Protein Engineering / methods*
  • Pseudoalteromonas / enzymology*
  • Pseudoalteromonas / genetics
  • Pseudomonas stutzeri / classification
  • Pseudomonas stutzeri / enzymology*
  • Pseudomonas stutzeri / genetics
  • Recombinant Proteins / metabolism
  • Species Specificity

Substances

  • Recombinant Proteins
  • Oxygenases
  • toluene 2-xylene monooxygenase